منابع مشابه
Protein translocation pulls the plug
Protein translocation pulls the plug embrane-bound compartments present an immediate problem: proteins need to get into and across those membranes. Now, we have the first picture of how that process works, thanks to the structure determined and colleagues. They find that a single SecY complex from Methanococcus jannaschii forms an hourglass-shaped pore with a basal plug that probably swings out...
متن کاملProtein Translocation How Hsp70 Pulls It Off
In an alternative mode, the Sec61 protein associates with a tetrameric Sec62/63p complex to form the SEC complex, a channel active in posttranslational transloca-heat shock 70 protein (Hsp70) called BiP, or Kar2p in yeast (Lyman and Schekman, 1997). BiP and the SEC complex are the only components required for translo-cation in a reconstituted system (Panzner et al., 1995); of A significant frac...
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C ancer cells have long been known to have higher rates of glycolysis than normal cells, a phenomenon named the Warburg effect after its discoverer Otto Warburg (1). Enhanced glycolysis is thought to allow cancer cells to survive the hypoxic conditions they experience in the center of solid tumors. But Mikawa et al. reveal how damaged cells switch off glycolysis as they enter senescence and sho...
متن کاملDNA Replication: Pif1 Pulls the Plug on Stalled Replication Forks
The conserved PIF helicase family appears to function in replication to ensure termination and passage through regions that slow or arrest replication fork movement. Findings in fission yeast extend evidence from budding yeast, and argue for universal mechanisms that ensure replication integrity.
متن کاملInvestigating the SecY plug movement at the SecYEG translocation channel.
Protein translocation occurs across the energy-conserving bacterial membrane at the SecYEG channel. The crystal structure of the channel has revealed a possible mechanism for gating and opening. This study evaluates the plug hypothesis using cysteine crosslink experiments in combination with various allelic forms of the Sec complex. The results demonstrate that the SecY plug domain moves away f...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1641rr1